The U.S. and Israel have launched strikes on Tehran, and President Donald Trump says the U.S. is starting major combat operations against Iran. Witnesses reported smoke near offices tied to Iran’s supreme leader on Saturday, and residents hear heavy explosions across the capital. Trump says Iran keeps pursuing nuclear work and missile development, and he warns U.S. casualties are possible. Iran says it has not enriched uranium since June, but it has blocked international inspectors from bombed sites. The Associated Press says satellite images show new activity there. Iraq closes its airspace, and Israel also shuts its airspace. Read moreThe Latest: Iran's supreme leader Khamenei killed in strikes, says Israeli officials

The U.S. and Israel have launched major attacks on Iran that President Donald Trump says aim to crush Iran’s military and stop production of a nuclear weapon. Iran fired drones and missiles at Israel and strikes aimed at U.S. military installations in Bahrain, Kuwait and Qatar. Several countries closed their airspace, and the exchanges of fire continued into the night. Iranian state media cited the Red Crescent as saying that at least 201 people have been killed. Israeli Prime Minister Benjamin Netanyahu said in a nationally televised address that there are “growing signs” that Supreme Leader Ayatollah Ali Khamenei has been killed. Read moreWhat to know about the new US-Israel attacks on Iran

Israeli officials told The Associated Press that Supreme Leader Ayatollah Ali Khamenei is dead. There was no immediate comment from the U.S. or Iran on his status. The assassination Saturday of the second leader of the Islamic Republic, who had no designated successor, would throw its future into doubt. In a nationally televised address, Israeli Prime Minister Benjamin Netanyahu said said there were “growing signs” that Khamenei had been killed when Israel struck his compound early Saturday. Read moreIsraeli officials say Supreme Leader Ayatollah Ali Khamenei is dead. No word from US or Iran

World leaders are responding cautiously after U.S. and Israeli strikes on Iran raised fears of a wider war. European leaders held emergency meetings and moved to protect citizens in the Middle East. Britain, France, and Germany urged the U.S. and Iran to restart talks. They condemned Iranian attacks in the region. The European Union calls the situation perilous and urges restraint and respect for international law. Russia called the strikes unprovoked aggression. China says it is highly concerned and calls for a halt. Australia and Canada expressed more support for the U.S. position. Read moreWorld leaders react cautiously to US and Israeli strikes on Iran as fears grow of a wider war

U.S. President Donald Trump said in an 8-minute video posted on his Truth Social platform that the U.S. has begun “major combat operations in Iran.” He claimed Iran ha… Read moreRead President Trump’s statement on Iran in full